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破解染色體混亂之謎：CRISPR-KOALA技術揭示81個基底樣三陰性乳癌驅動基因

西奈健康研究所嘅Lunenfeld Tanenbaum研究所團隊開發咗全新基因編輯工具CRISPR KOALA，可以同時激活同沉默基因，喺活體動物模型中進行大規模基因篩查團隊針對3,700多個位於三陰性乳癌常見染色體異常區域嘅基因進行篩選，最終發現咗81個全新嘅致癌基因令人驚訝嘅係，呢81個基因中有90%完全被之前嘅大型癌症基因組研究忽略咗

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Illustration of CRISPR gene-editing tool targeting DNA strands, representing the CRISPR-KOALA technology developed for breast cancer research. — Search & fact-check with cited sources for What did a team of scientists at Sinai Health in Toronto discover about basal-like triple-negativAn artistic representation of CRISPR gene editing. The new CRISPR-KOALA tool can simultaneously activate and silence genes in living animal models.
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Create a landscape editorial hero image for this Studio Global article: Search & fact-check with cited sources for What did a team of scientists at Sinai Health in Toronto discover about basal-like triple-negativ. Article summary: A team of scientists at the Lunenfeld-Tanenbaum Research Institute, part of Sinai Health in Toronto, developed a new gene-editing tool called **CRISPR-KOALA** and used it to identify **81 previously unknown genes that dr. Topic tags: general, government, academic, general web, user generated. Style: premium digital editorial illustration, source-backed research mood, clean composition, high detail, modern web publication hero. Use reference image context only for broad subject, composition, and topical grounding; do not copy the exact image. Avoid: logos, brand marks, copyrighted characters, real person likenesses, fake screenshots, UI text, readable text, wate
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多倫多西奈健康研究所旗下嘅Lunenfeld-Tanenbaum研究所團隊，開發咗一種全新嘅基因編輯技術叫CRISPR-KOALA，並用佢成功識別出81個之前完全唔知道嘅、會驅動基底樣三陰性乳癌（basal-like triple-negative breast cancer）嘅基因。呢項研究成果已經喺2026年7月左右刊登喺頂級科學期刊《自然》（Nature）上面。

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新技術突破： CRISPR-KOALA克服咗傳統CRISPR篩查嘅一個重大限制——佢可以同時激活同沉默基因，畀研究人員喺同一隻動物模型入面，系統化噉測試數以千計基因喺活體組織入面嘅功能。
大規模篩查： 團隊針對超過3,700個、位於三陰性乳癌腫瘤入面經常出現變異（擴增或缺失）嘅染色體區域嘅基因進行咗仔細篩查。

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